Speaker: Larnii Booth
Affiliation: University of Queensland

Abstract:

Motor molecules are a type of biological molecule that take chemical energy and convert it to mechanical work. They perform the manual functions in a cell which are crucial for any living organism, but their dynamics are poorly understood as they are extremely hard to detect because of their size (typically smaller than 50nm) and their speed (>100Hz), making direct optical imaging of single molecules impossible. Even though they have been observed by attaching labels to biomolecules, it has been shown that these labels can severely impede the normal function of biological molecules.   

For these reasons, unlabelled biosensing has been developed. Unlabelled biosensors have used plasmonics and optical micro resonators to detect molecular dynamics, however, they use high intensities which are known to damage biological samples, preventing the observation of healthy molecular motor for an extended period of time. Quantum limited sensing has been demonstrated as a solution to this, as it allows the sensor to operate at much lower intensities, however, current implementations with nanofibres do not have the resolution to resolve motor molecule dynamics. In my talk, I will first present a novel way to model optical radiation of bio-molecules using the interactive dipole model for a better prediction of the signal of unlabelled biosensors. I will also show how to combine the advantages of optical resonantors sensor with quantum limited detection using a photonic crystal cavity device. Photonic crystal cavities possess highly confined electric field, offering a high resolution required to observe molecular motors. Design and fabrication of this new type of sensor will be presented which can potentially allow detection of motor molecule dynamics at optical intensities below the damage threshold for biological samples.

About Physics Seminars

The weekly Physics Seminar series focuses on a broad range of physics research within SMP, along with frequent presentations from visiting researchers. Seminars are usually scheduled for 1.00pm on Tuesdays.

The talks are typically more specialised than a colloquium but are often attended by staff and PhD students across a broad range of areas. Speakers are thus encouraged to include introductory material in the talks.

All SMP researchers and HDR students are encouraged to speak. Please email Tyler Neely to register your interest.

The seminars are open so there is no need to register your attendance.

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Venue

Zoom address:
https://uqz.zoom.us/j/94116861984