Mathematical and Experimental Models of Cell Invasion with Fluorescent Cell Cycle Indicators
Abstract: Fluorescent cell cycle indicators, such as FUCCI, allow us to visualise the cell cycle in individual cells. FUCCI reveals real-time information about cell cycle dynamics in individual cells, and can be used to explore how the cell cycle relates to the location of cells, local cell density, and different microenvironments. In this talk we will describe how FUCCI technology can be incorporated into continuum and discrete models of cell invasion. Using experimental data from scratch assays with FUCCI-transduced melanoma cells, we show how mathematical models can be used to predict key features of the experiments. Some analysis of travelling wave solutions of the models will also be presented.
About Applied and computational maths seminars
Our seminars bring together UQ's applied and computational mathematics communities.
UQ and invited scientists deliver the presentations, which are informal and promote discussion.
We welcome suggestions for speakers and topics from staff, students and visitors, and encourage students to share their work.
Our seminars are usually held on Thursdays from 3pm to 4pm.
To suggest a topic or speaker, and for more information, contact Dr Dietmar Oelz or Dr Cecilia Gonzalez Tokman.